Clenbuterol HCL Overview
Clenbuterol is a widely used potent and long-lasting bronchodilator. It is used in many parts of the world. It is most often prepared in 2Omcg tablets, but Clenbuterol is also available in 40mcg pills, syrup and injectable form. This drug belongs to a broad group of drugs knows as sympathomimetics. Clenbuterol HCL affects the sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors.
Clenbuterol HCL Uses
The drug is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that Clenbuterol has little beta-i stimulating activity. Since beta-i receptors are closely tied to the cardiac effects of adrenoceptors, this allows to reduce reversible airway obstruction (and effect of beta-2 stimulation) with much less cardiovascular side effects compared to non-selective beta agonists. Clinical studies with Clenbuterol show it is extremely effective as a bronchodilator , with a low level of user complaints and high patient compliance Clenbuterol also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours long. This makes steady blood levels easy to achieve, requiring only a single or twice daily dosing schedule at most. This of course makes it much easier for the patient to use, and may tie into its high compliance rate. Clenbuterol HCL is available in a wide number of other countries however, Clenbuterol has not been approved for use in the United States. The fact that there are a number of similar to Clenbuterol, effective asthma medications already available in this country may have something to do with this, as a prospective drug firm would likely not find it a profitable enough product to warrant undergoing the expense of the FDA approval process. Regardless, foreign Clenbuterol preparations are widely available on the U.S. black market.
Clenbuterol Hydrochloride, or Clen as it is known, is becoming very popular with anybody who wants to lose weight fast, mainly due to some celebrities who have admitted to using Clenbuterol tablets to lose weight for concerts and/or acting roles where they needed to lose some pounds fast.
Clenbuterol is currently not controlled under the Controlled Substances Act (CSA). However, Clenbuterol is listed by the World Anti-Doping Agency and the International Olympic Committee as a performance enhancing drug and therefore athletes are barred from its use. At present, no states have placed Clenbuterol under control.
"Those who claim to be in the know have named Clenbuterol the celebrity quick fix of the season. Recently, on the gossip website Popbitch, one spoilsport pointed the finger. "LA’s current concentration-camp look isn’t just the result of cocaine and eating disorders," said the post. "Everyone’s doing Clenbuterol. Prescribed as an asthma medication, [it] is taken by body-builders and now weight-watchers for its amazing fat-burning qualities…
Independent.co.uk"
How Clenbuterol HCL Works
Clenbuterol is shown to stimulate fat cells to breakdown and form free fat acids, thus increasing your metabolism. It will also increase muscle strength, by allowing more oxygen to be used by cells that need it. Fat brake down process will keep your body temperature slightly over normal (half of a degree or so). These properties make Clenbuterol an excellent choice, if your goal is to reduce your overall body fat. It is thought that a 1°F increase in body temperature yields around a 5% increase in maintenance calories burned - this is the process that Clenbuterol uses to burn fat without dieting.
Clenbuterol HCL and fat loss
When using Clenbuterol for fat loss - the primary effect of Clenbuterol - it seems to work well for approximately 4-6 weeks. During this period, users will want to constantly monitor their body temperature. We are assured Clenbuterol is working by the temperature elevation. Once the temperature drops back to normal, this drug is no longer exhibiting a thermogenic effect. At this point increasing the dosage would not be very effective, and a break for at least a few weeks should be taken before it is used again effectively.
If one is looking for strength gains, it appears to be effective for a much shorter period of time, around 3-4 weeks. This may be due to an absence of real anabolic effect, with the strength gain seen with Clenbuterol possibly due only to the stimulant properties of the drug (similar to the strength boost seen by Ephedrine users). Again however, this is still debated.
Clenbuterol and Cytomel T3/T4
Many competitors also find the fat burning effect of Clenbuterol can be further enhanced by additional substances. Combining Clenbuterol HCL with thyroid hormones, specifically the powerful Cytomel T3, the thermogenic effect of Clenbuterol can become extremely dramatic. This can be to a point that the athlete could shred exceptional amounts of extra fat during contest preparations, without a dramatic restriction in calories. A clenbuterol/thyroid mix is also common when using growth hormone, further enhancing the thermogenic and anabolic effect of this therapy.
Adrenoceptor in Clenbuterol
There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number. Depending on the specific affinities of these agents for the various receptors, they can potentially be used in the treatment of conditions such as asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches and anaphylactic shock. The text Goodman and Gillman's The Pharmacological Basis of Therapeutics 9 Edition does a good job of describing the diverse nature in which these drugs affect the body:"Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types: (1) peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands; (2) a peripheral inhibitonj action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle; (3) a cardiac excitatory action, responsible for in increase in heart rate and force of contraction; (4) metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue; (5) endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones; (6) CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite; and (7) presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as such as norepinephrine and acetylcholine." |
